New chemical reactions are essential components to advance numerous fields in science. The most powerful and efficient chemical reactions commonly use catalysis to control reactivity and selectivity. Recently our laboratory has developed the use of bifunctional thiourea organocatalysts for the stereoselective Horner-Wadsworth-Emmons olefination reaction. In our presentation we will describe the identification of bifunctional amine thiourea catalysts that will react with a wide range of carbonyl electrophiles to produces alkenes, and application of these catalysts to the development of a catalytic stereoselective Horner-Wadsworth-Emmons reaction. The development of this general strategy provides a reaction of broad utility beyond the standard manifold used in alkene formation.

Bifunctional catalyst controlled stereoselective Horner-Wadsworth-Emmons reaction

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.