Hollow silica nanoparticles are of great interest for applications in many fields due to their special structure, inner cavity, and high specific surface area. In this work, hollow mesoporous silica nanoparticles were prepared via a rapid, scalable and simple method (flash nanoprecipitation) by using cetyltrimethylammonium bromide (CTAB) as template and pore forming agent in a multi-inlet vortex mixer. During the preparation process, the size and size distribution of mesoporous silica nanoparticles were found to be tunable by changing the type and proportion of silicon source and the velocity ratio of four flows. This study lays a foundation for continuously large-scale preparation of silica nanoparticles with controllable size.

Preparation of hollow silica nanoparticles by flash nanoprecipitation

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