Treatment of brain diseases remains a challenge due to the difficulties of therapeutic agents' delivery. Specifically, the application of hydrophobic neuro-regenerative drugs was limited due to their poor bioavailability caused by insolubility and short half-life. An effective approach of targeting and control on release was also needed for efficient delivery. Herein, we presented our study on applying an easy and fast method of surface functionalization on a light-responsive drug delivery vehicle, the core-shell superparamagnetic iron oxide-gold nanoshell (SPIO@Au) nanoparticles. With assistance from anion exchange resin (AER), the high rate of surface modification via Thiol-PEG-Pyrene bridging with PCC-3 (Porous coordination cages) was realized. Higher drug loading efficiency and better colloidal stability were achieved through this method. The scope of nanoparticles can be expanded to hollow gold nanoshell (HGNS), which has the feature of 808 nm surface plasmonic resonance wavelength. Besides characterizations, a demonstration of the controllable release of retinoic acid (RA) from as-designed drug carriers was performed. The light-treated group showed more complete (88% in just 1 day) release compared to the control group (less than 60%). Most loaded RA can be released before the time frame it will be removed from the body.

Enhanced surface functionalization on superparamagnetic iron oxide – gold nanoparticles toward drug carriers with higher loading capacity and bioavailability

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.