Carnosic acid (CA) has attracted considerable attention owing to its potential health benefits. However, its application has been limited by low gastrointestinal dissolution and a lack of food-grade delivery systems. This study aimed to enhance bioaccessibility and bioactivities of CA using edible nanoparticles and to examine delivery efficiency using <i>in vitro</i> models. CA in zein/carboxymethyldextran nanoparticles (CA NPs) presented as homogenous spheres with an average size of 179 nm and ζ-potential around -28.4 mV. The bioaccessibility of CA in NPs enhanced significantly as demonstrated by higher dissolution in simulated digestive fluid and improved intestinal absorption in the dynamic TNO gastrointestinal model (TIM-1). Additionally, the anti-lipogenic and G0/G1 cell cycle arresting activities of CA NPs also exhibited equivalent efficacy compared to CA in DMSO in differentiated 3T3-L1 cells. These results indicated that zein/carboxymethyldextran nanoparticles could serve as an effective oral delivery system for CA to exploit its application in the functional food industry.

Improving bioaccessibility and anti-lipogenic activity of carnosic acid using zein/carboxymehtuldextran nanoparticles

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ACS Fall 2022

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