The emergence of multidrug resistant microbial species suggests that novel prevention and therapeutic strategies are urgently needed. Vaccines are a powerful tool to reduce rates of infection. It is well appreciated that carbohydrates on the surface of microbial cells can be attractive targets for vaccines. However, there are multiple challenges associated with carbohydrate-based vaccine development. The first obstacle lies in the access to microbial associated glycans as carbohydrates from microbial species often have distinctive structures compared to the mammalian counterparts, and can present unique reactivities in glycosylation reactions. The synthesis of these compounds in conjugatable forms needs to be established. Furthermore, carbohydrates alone typically have low immunogenecities, which do not elicit high level and long-lasting antibody responses. Therefore, methods are needed to powerfully boost the immune responses to carbohydrate antigens. In this presentation, our efforts to address some of the challenges in the development of carbohydrate based anti-microbial vaccines will be discussed.

Development of carbohydrate based anti-microbial vaccines

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.