Biologically active compounds, such as polyphenols, have become an intense focus of research interest because of their perceived health-beneficial effects. They occur in a variety of fruits, vegetables, nuts, seeds, flowers, bark, beverages, and even some manufactured food, as a component of the natural ingredients used. They have been reported to exhibit anti-carcinogenic, anti- atherogenic, anti-ulcer, anti-thrombotic, anti-inflammatory, immunomodulating, anti- microbial, vasodilatory, and analgesic effects. Natural deep eutectic solvents (NADES) were first described by in 2011 and they are able to fully address the requirements of “ideal solvents” such as: non-volatile (reduced air pollution), non-flammable (process safety), stable (easier recycling and reuse), biodegradable, non-toxic, inexpensive and based on renewable sources. NADES fully represent green chemistry principles. Thus, they have been considerate as a new generation of chemicals with potential uses in various industrial fields. Indeed, as environmentally friendly solvents, they have been allowed by US Food and Drug Administration to be used in food, cosmetic and pharmaceutical formulations. In this paper we present the study on polyphenols extraction by different NADES mixtures from onion bio-wastes. Physico-chemical properties (such as viscosity, pH, density) of 10 different NADES mixtures have been investigated and their influence on BACs extraction yield will be discussed. Moreover, effect of ultrasound treatment on the extraction efficiency will be presented.

Extraction of biologically active compounds  from bio-waste by using environmentally friendly NADES solvents

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