Hydrogen atom transfer from C–H bonds in carbohydrate derivatives offers access to radicals that can be employed in diverse and useful reactions, including oxidations/reductions, epimerizations and homologations. Because steric and electronic differences between the C–H bonds in sugars are relatively subtle, achieving site-selectivity is a challenge. In this presentation, I will discuss my group’s progress towards devising new radical reactions of carbohydrates using photoredox and hydrogen atom transfer catalysis, including C-alkylation, oxidation, and ketodeoxysugar formation. Mechanistic analysis and computational studies will be discussed.

Site-selective radical reactions of carbohydrates

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.