<br/>Due to its biodegradable and biocompatible nature, polylactic acid (PLA) has found widespread use in biomedical applications. Controlled drug delivery using PLA-based nanoparticles (PLA-NPs) is an important tool to tuning bioavailability of therapeutics. Traditional methods to prepare PLA-NPs require a multistep process that is time consuming and produces significant aqueous and organic waste streams. This work reports a one-pot mechanochemical synthesis of lactide to PLA-NPs. Our results demonstrate a minimal waste generating robust optimized one pot method for preparing precisely defined nanoparticles.

One pot phenolic-initiated mechanochemical synthesis of poly(lactic acid) nanoparticles

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.