The Diels-Alder (DA) reaction is one of the most important organic transformations in organic synthesis for the construction of six membered ring systems. DA reactions between dienes and dienophiles usually requires high boiling solvents and elevated temperatures. Here, we present a Diels-Alder reaction performed under mild conditions using a catalytic amount of proline and a resorcinarene-based molecular capsule that can confine the reactants in their nano space. Topics will include optimization, substrate scope, and mechanistic experiments.

Organosupramolecular-catalyzed Diels-Alder reaction

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