The development of a nickel-catalyzed Kumada cross-coupling reaction of benzylic sulfonamides will be presented. The use of benzylic amine derivatives in nickel-catalyzed cross-coupling reactions has previously been limited to charged ammonium salts and strained aziridine rings. The scope of the Kumada cross-coupling reaction including cyclic and acyclic benzyl amine derivatives will be discussed. Preliminary evidence suggests that the reaction proceeds via a stereospecific mechanism to rapidly afford acyclic fragments bearing 1,3-substitution. In addition, recent developments of a nickel-catalyzed conjunctive cross-electrophile coupling reaction will be discussed.

Nickel-catalyzed Kumada cross-coupling reactions of benzylic sulfonamides

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