Enzyme-based nanobiohybrids (EnNBHs) are an emerging biocatalyst family that can manufacture industrial products such as biofuels and biochemical in a green and low-carbon manner. Designing high-performance EnNBHs can confer the enzymes with superior robustness and durability, while current strategies confront grand challenges. Herein, a facile and versatile <i>in situ</i> entrapment strategy is developed to entrap a series of enzymes in imine-based covalent organic networks (CONs) under mild conditions. Enzymes can promote the nucleation and growth of CONs while the CONs coating can act as a protection layer for the enzymes. The external CONs can safeguard the hosted biomolecules from being denatured under unfavorable conditions, such as high temperature, strong acidic/basic conditions, organic solvents, etc. Given the short-range ordered open porous structure, CONs can offer rapid transport channels for substrates and products, exhibiting superior catalytic efficiency. Furthermore, CONs can be endowed with biofunctionality and serve as a cell-mimic nanoreactor for multienzyme catalysis, demonstrating great potentials in biomedicine, biosensing and so on.

Covalent organic networks for in situ entrapment of biomolecules with superior robustness and durability

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.