Resveratrol (RSV) has been confirmed to confer multiple health benefits, and majority of RSV tends to be metabolized in the gut microbiota after oral administration. In this study, the metabolism of RSV was investigated by using mouse models with distinct gut microbiota compositions: germ-free mice colonized with a single bacterial species named Ligilactobacillus salivarius Li01 (Li01), conventional mouse model with healthy gut microbiota, and DSS-induced colitis mouse model with disturbed gut microbiota. The results demonstrated that in feces, the metabolites of RSV, including resveratrol sulfate (RES-sulfate), resveratrol glucuronide (RES-glucuronide), and dihydroresveratrol, significantly increased after Li01 colonized in germ-free mice. Furthermore, RES-sulfate and RES-glucuronide were below the detect threshed in the feces of conventional mice, with dihydroresveratrol being the dominant metabolite. Compared to the conventional mice, the ratio of Firmicutes/Bacteroides and the abundance of Lactobacillus genera were found significantly elevated in colitis mice after long-term ingestion of RSV, which shifted the metabolism of RSV in return. Furthermore, an increased DHR/RSV ratio was confirmed to contribute to enhanced anti-inflammatory effect in colitis mouse model. Our study provided critical implications in further application of RSV in foods and food supplements.

Gut microbiota composition in relation to the metabolism of oral administrated resveratrol

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ACS Fall 2022

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