Isoindoles, nitrogen-containing heterocycles are interesting skeletons and have attracted considerable attention from organic chemists due to their medicinal, fluorescent, electroluminescent properties, and a high level of reactivity in cycloaddition reactions. Isoindoles are abundant structural motifs in a variety of natural products, biologically active, pharmaceutical compounds, and organic light-emitting devices (OLEDs). Therefore, new methods for the synthesis of uncommon isoindole-containing heterocycle cores are of particular interest. Here, using 13C- and 15N-labeled precursors, we have demonstrated how 13C-15N hetero nuclear coupling NMR spectrometry can be utilized to discover novel chemical transformations leading to isoindole-containing heterocycles. This novel NMR tool can be utilized to discover novel transformations beyond isoindole chemistry.

13C-15N hetero nuclear coupling NMR to facilitate novel isoindole chemistry

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ACS Fall 2022

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