Nitrosobenzene’s have a wide variety of uses in organic synthesis as they act as an excellent precursor for the synthesis of nitrobenzene and amines. They can also be used in the synthesis of secondary and tertiary hydroxylamines through mild aldol reactions. Traditional methods for the synthesis of nitrosobenzenes involve harsh reaction conditions with the use of strong oxidants, with poor functional group tolerance. To overcome these limitations, we have developed a mild one-pot, two-step synthesis of nitrosobenzene from arylborons (boronic ester, boronic acids and trifluoro-borates) with the use of bench-stable reagents. This method has great functional group tolerance and simple purification to produce pure nitrosobenzene in excellent yield.

New method for synthesis of nitrosobenzene from arylborons

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