Transmembrane proteins such as TRPV1 are located in the brain and the peripheral neurons are responsible for facilitating action potentials that elicit pain responses. In order to elicit pain responses, action potentials are often fired in the neurons. Research has shown that vanilloids, capsaicin, and temperature increase have been shown to open the lower pore in the TRPV1 ion channel. Here, we will discuss the implications of a replica exchange simulations on the ligand-gating and temperature-activation mechanism of TRPV1.

Determining the heat-activation and ligand gating mechanism of TRPV1

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.