Because of the increasing antibiotic resistance of the pathogens, new materials with significant antibacterial effect are highly demand. In this work, a series of fluorescent cationic conjugated agents are designed to interact with two different bacteria, Gram-negative <i>E. coli </i>and Gram-positive <i>S. aureus</i>. The reactive oxygen species (ROS) of these cationic conjugated agents are generated under light irradiation, which can effectively kill the bacteria. Meanwhile, the fluorescent images of the bacteria after incubation and irradiation with different time and concentration of different cationic conjugated agents are recorded using confocal fluorescent microscopy (CFM). With this method, the interaction between bacteria and cationic conjugated agents in real time is monitored, the differences can be compared and further studied.

Fluorescent cationic conjugated agents for effective antibacterial application

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ACS Fall 2022

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