Micro and nano sized materials are significant in the biomedical space when considering how to design for tissue infiltration and healing upon implantation of new devices. Electrospinning offers a unique opportunity as a processing method that compatible with a wide array of polymers and conditions that may all be tailored to produce similar morphologies in the resultant 3D porous scaffolds. An additional benefit of electrospinning is the ability to incorporate external stimuli, such as light, to drive <i>in situ</i> reactions including thiol-ene photoclick reactions to produce thermoset polymer network fibers during the jetting process (the fiber forms simultaneously with the network as the liquid jet moves from the nozzle to the plate and is irradiated along the pathway). Here, a series of bioderived, pro-drug photopolymers, derived from salicylic acids, are photocrosslinked, in the presence of polystyrene and silver sulfate, during jetting to achieve a series of composite fibrous mats. The mats were examined for physical properties to determine the role of the polystyrene, silver sulfate, and fiber morphology. Of specific note, these materials display shape memory, allowing for minimally invasive medical device opportunities, as well as cytocompatibility and antimicrobial behaviors. Ultimately, these composite fibrous mats display excellent promise for both implantable tissue scaffolds as well as for medical devices including face masks or wound coverings.

Photopolymer electrospun fibrous mats derived from natural product pro-drug salicylic acid

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.