The rapid diversification of unprotected amines using organometallic approaches remains an outstanding desirable approach to allow access to new drug-like molecules. Using the inherent directing ability of the amine portion of an allylamine, we have discovered that it is possible to install alkynyl groups at the gamma-position of allylamines under Pd catalytic conditions. Topics will include how we optimized the reaction, as well as initial exploration of the substrate scope for the transformation.

Pd(II)-catalyzed gamma-alkynylation of allylamines

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.