RNA is upstream of all biology and thus presents a vast array of therapeutically attractive targets.  Most therapeutic agents that bind directly to RNA are either antibiotics blocking bacterial ribosome function or oligonucleotides with their attendant pharmaceutical limitations.  At Arrakis we identified druggable RNA sub-structures in mRNA and orally available small molecules that bind to those structures selectively and thereby modulate mRNA function.  This presentation will focus on some of the unique challenges of drugging RNA, offer some solutions to these challenges, and provide some early data on targets of interest.

Drugging proteins to drugging RNA: A transition in drug discovery

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.