The Cope Rearrangement is a classic transformation of value to organic synthesis. Certain substrates classes (<i>e.g. </i>oxy-Cope substrates) have been well developed due to their ready availability and generally favorable energetic profiles. Conversely, 3,3-dicyano-1,5-dienes have been overlooked. We have been exploring 3,3-dicyano-1,5-dienes and have uncovered strategies to improve their energetic profiles in general ways that impact their applicability to complex molecule synthesis. This seminar will focus on<i> how the marriage of theory and experiment</i> has impacted Cope rearrangement-centered strategies for complex molecule synthesis.

Contrathermal cope cope rearrangements through theory, design, and experiment.

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.