The presentation of bioactive moieties in terms of multivalency, ligand density, and architecture plays a central role in biological recognition processes, including cellular adhesion and pathogen binding. Polypeptoids that self-assemble into two-dimensional (2D) nanosheets have potential to recapitulate these precise molecular recognition motifs onto a flexible platform for biosensing. The traditional solid-phase method for the synthesis of peptoids allows for precise control over the placement of potential recognition sites in the sequence, yet generates molecules on a small scale (~100 mg). Recent solution-phase synthetic methods have enabled gram-scale synthesis, but lack sequence-specificity needed for self-assembly and precise incorporation of molecular recognition motifs. Herein, we present our motivations and efforts in bridging this divide.

Sequence-controlled peptoid polymers via iterative exponential growth

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ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.