This contribution demonstrates effective routes into drug-like entities achieved by exploiting photoisomerisation cascades in continuous flow mode. The application of tunable high-power LEDs in the UV and visible range in comination with flow reactor technology provides for superb process control and scalability to prepare multigram quantities of targets including quinolines, oxazoles as well as polycyclic products arising from a new photocascade discovered in our laboratories. The use of light instead of stoichiometric reagents in comination with 100% atom economy provides for attractive features with respect to modern sustainability principles.

Continuopus flow photochemistry for the greener generation of drug-like entities

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ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.