In situ monitoring is a powerful tool, allowing chemists to track a reaction in real time and under synthetically relevant conditions. Such investigations reveal critical observations, such as intermediates and rate dependencies, which are essential to understand a reactions kinetics and can help elucidating the underlying mechanism. The ultimate goal is a mechanistic hypothesis-driven reaction optimization. In this talk, I will present a comprehensive kinetic examination of a model esterification, performed by the state-of-the-art homogeneous photocatalyst Ir(ppy)3 and a heterogeneous photocatalyst (graphitic carbon nitride). In-depths kinetic studies of both catalytic systems had been undertaken, using in situ IR, data processing has been done by applying variable time normalization analysis (VTNA). Further, a kinetic study of the photocatalyzed oxidative cleavage of benzyl ether protecting groups on carbohydrates will be presented. An in situ illumination-NMR spectroscopy setup has been used to study the reaction and support a mechanistic hypothesis.

Mechanistic insights through in situ monitoring in photocatalytic synthesis

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ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.