Amines are ubiquitous functional groups that are simple to prepare and functionalize. We show that tertiary amines can be used to template reductive cyclization reactions, forming biaryl and bibenzyl C–C bonds. These cyclic amine products can undergo amine rearrangement and deaminative contraction reactions, providing efficient access to polyaromatic natural products. These strategies and our understanding of deaminative mechanisms will be presented.

Amine-templated strategies, amine rearrangements, and deaminative contractions for the synthesis of natural products

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ACS Fall 2022

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