This project aims at optimizing the preparation of isobutenylglycine-based compounds and using them to explore various subsequent chemical transformations. These building blocks could prove useful in the synthesis of natural products, such as the members of the celogentin family. Additionally, they could serve as stable precursors for vinylglycine derivatives.<br/>The unusual amino acid vinylglycine and a number of related compounds have been studied throughout the years for their special reactivity and involvement in certain biological processes. Given the presence of an alkene moiety, the structures can be manipulated through a variety of chemical reactions. While the preparation of vinylglycine itself has been extensively investigated in the past, its production is still problematic due to its sensitivity to racemization and isomerization, which renders key steps irreproducible during its synthesis and the preparation of derivatives. We propose that appropriately substituted isobutenylglycine-based building blocks may be safe from decomposition and could serve as shelf-stable precursors to valuable materials. Our progress in these endeavors will be presented.

Use of isobutenylglycine derivatives as building blocks for complex molecule synthesis

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.