The study investigated the preventive effect of 5-demethylnobiletin (5DN), a natural polymethoxyflavone derivative from citrus fruits, on dextran sulfate sodium (DSS)-treated mice and its potential mechanisms. The results indicated that 5DN treatment alleviated DSS-induced colitis symptoms in mice by preventing body weight loss, reducing disease activity index, decreasing the colon weight to colon length ratio, and lessening colonic tissue damages. Additionally, 5DN inhibited the immune response in colitic mice through descending the production of inflammatory cytokines. Furthermore, 5DN altered the gut microbiota dysbiosis in DSS-treated mice via up-regulating the level of probiotics (Roseburia) and down-regulating the level of pathogenic bacteria (Clostridium, Parabacteroides, and Sutterella). Taken together, these data provided a solid scientific basis for utilizing 5DN as a therapeutic candidate in colitis and related diseases.

Dietary 5-demethylnobiletin attenuated dextran sulfate sodium-induced colitis in mice by inhibiting the immune response and regulating gut microbiota

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ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.