Using second harmonic generation, we monitored adsorption of water-soluble peptoids to phospholipid bilayers at varying pH conditions and temperatures. We compared equilibrium binding constants and relative surface coverages of different peptoid sequences as we varied the cholesterol content, head group charge and physical phase of the lipid bilayers. We also collected pressure-area isotherms of lipid monolayers in the presence and absence of peptoids to gain insight into the physical principles that govern how peptoid sequence and membrane composition alter peptoid–lipid interactions.

Peptoid structure impacts interactions with phospholipid bilayers and monolayers

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ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.