Endohedral metallofullerenes are a special type of materials that have metal ions encapsulated in a fullerene carbon cage. They provide a valuable interface that allows organic chemists to operate on metal ions and clusters for applications that are otherwise difficult to achieve. For example, they can provide definitive encapsulation of toxic lanthanide ions for biomedicines, such as magnetic resonance imaging (MRI) and computerized tomography (CT) contrast agents. However, it is very challenging to modify the hyphobic fullerene cage and make them water-soluble in a molecularly precise manner. In this talk we present our effort of building a "metallobuckytrio platform", that is modular for synthesizing precise water-soluble metallofullerene derivatives based on isomerically pure mono-functionalization. We will present the study of their aggregation in water, and MRI contrast performance. The tailorable platform will allow chemists to access a wide range of water-soluble functional metallofullerene derivatives with desirable ligands.

Molecularly precise water-soluble metallofullerene derivatives based on a metallobuckytrio platform

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ACS Fall 2022

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