The resveratrol family, consisting of polyphenolic natural products, has broad appeal to the synthetic community due to their observed antioxidant and other general biological activity. To allow rigorous biological evaluation of these molecules, their total synthesis is being pursued. The Stephenson lab has worked to utilize a biomimetic strategy, harness persistent free radicals to construct the framework of these secondary metabolite natural products. This work continues our lab’s interest in free radicals as a versatile and sustainable method that is yet to be fully realized in natural product synthesis. This strategy has allowed the rapid and efficient construction of motifs that have proved difficult to reach via classical synthetic methods.

Biomimetic synthesis of oligomeric resveratrol natural products enabled by free radicals

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.