Molecular assembly from ultra-small solution droplets follows a different dynamic from that of larger scales. Combining microfluidic probe with atomic force microscopy (AFM), sub-femtoliter aqueous droplets containing designated solutes, e.g., polymers, organic and inorganic molecules, produce well-defined features with dimensions as small as tens of nanometers. This presentation reports that the new attempts to extend the concept to lipid molecules, which present larger challenges than prior efforts, due to their amphiphilic structures, and strong tendencies to self-assembly. Utilizing the ultrafast evaporation rate and spatial confinement by the small droplets, this work demonstrates that molecular assembly could be controlled and regulated in terms of feature geometry, distribution and packing of individual molecules within features. This work introduces new means of control over molecular assembly, bringing us closer to programmable synthesis for chemistry and materials science. The outcomes pave the way for 3D nanoprinting in additive manufacturing.

Controlled assembly of lipid molecules

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.