Realizing maximum tumor suppression along with preventing tumor regrowth by optimizing the photons usage in phototherapy remains a major challenge. Herein, a mitochondrial-targeted phototheranostic nano-formulation (MsPDTT NPs) was prepared from molecular theranostic encapsulated into phospholipids. Notably, under single 690 nm laser excitation, MsPDTT NPs can perform dual-mode photoacoustic and near-infrared fluorescence (PA/NIRF) imaging and potent PDT/PTT due to efficient excited-state deactivation pathways (through radiative and energy transfer to generate reactive oxygen species and non-radiative relaxation). The reference RsPDTT NPs lacking mitochondrial targeting feature exhibits only PTT property. Based on biological results, MsPDTT NPs therapeutic response can be switched to PDT and PTT under a normoxic and hypoxic environment and maximize the overall efficacy of phototherapies without any noticeable side-effects. The current finding suggests the potential of using simultaneous PDT/PTT with proper photon utilization as a promising theranostic approach for hypoxic tumor photoablation.

Harnessing a single-laser-activated dual photoactivable organic nanotheranostic for maximal photon usage

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.