In the last decade, the food industry and consumers are more interested in the development, production, and consumption of non-conventional food products that fulfill health claims. Additionally, lifestyle diseases (e.g. hypertension, obesity, and/or diabetes) were the most significant comorbidities during SARS-CoV-2 Pandemia. Thus, edible products enriched with health-promoting ingredients are desirable foods to prevent those diseases and enhance the immune system. Camu-camu (Myrciaria dubia (Kunth)McVaugh) is a tropical fruit belonging to the Myrtaceae family that occurs in flooded areas throughout the Amazon region from Brazil, Peru, Colombia, and Venezuela. It has been recognized by the high amount of vitamin C (ca. 4 g ascorbic acid/100 g), phenolic compounds, ellagitannins, and anthocyanins, among others. The antihyperglycemic activity potential of malic acid derivatives was studied by molecular docking experiments, with the aim to increase the knowledge of this activity in Myrciaria dubia fruit. For this purpose, a consensus approach was implemented using the scores obtained from five docking programs with different scoring bases (i.e., Molegro, LibDock, CDocker, Autodock/Vina, and PLP) to rank the test compounds as binders of the active site of α-glucosidase and α-amylase. After this ranking, substitution-dependent behavior was observed. Results allow considering this fruit as raw material for the development of functional foods.

Molecular docking studies of Camu-Camu (Myrciaria dubia) fruit bioactive compounds

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