Synthetic nanoreactors, capable of achieving speedy bioorthogonal catalytic transformations on-demand despite of the highly complex bio-environment and uncontrollable reaction conditions, have great significance in biomedical science and chemical biology. But, such bio-applicable catalytic platforms, where rate of the reactions can be remotely induced and controlled, have been little synthesized and applied. In this talk, I will present our recent efforts to design and synthesize catalytic hollow nanoreactors for promoting organic reactions in complex bio-media and living cells, using a remotely operable magnetic field- or light-induced effects. As the key synthetic strategy for catalytic nanoreactors, we could functionalize interior space and surfaces of hollow silica nanoparticles in spatio-specific manner, by adopting the nanospace-confined reaction approach that has been pursued by our group over the years. Owing to the synergy between localized thermal-effects and catalytic activities of functional nanocrystals, integrated within a protected and confined nanosized space, the developed hollow nanoreactors could efficiently and selectively affect the transformation of small-sized organic molecules in physiologically relevant complex conditions and, moreover, remotely control the bioorthogonal catalytic synthesis in living cells with highly accelerated reaction rates. I will also discuss our research directions towards versatile and adaptable method for efficient activation of diverse catalytic reactions inside living systems and expanding the scope towards the development of new and versatile bioorthogonal chemistry-methodologies.

Hollow nanoreactors as catalytic Platform for bioorthogonal synthesis in living systems

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ACS Fall 2022

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