Mycobacteria, which cause diseases ranging from tuberculosis to leprosy, have distinctive cell envelopes composed of numerous unique glycans that contribute to bacterial growth and virulence. Several groups, including ours, have developed chemical probes that metabolically label mycobacteria-specific cell surface glycans. These tools have been used to image mycobacterial glycans, probe glycan biosynthesis and remodeling, profile glycan-binding proteins, and rapidly detect mycobacteria. They have also inspired new glycan-targeting therapeutic strategies that may help to address challenging-to-treat mycobacterial infections. This presentation explores how research on chemical probes has led to insights that spurred the development of metabolic inhibitors and immune-targeting strategies for mycobacteria.

Chemical probes for mycobacterial glycans: From tools to therapeutic opportunities

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.