Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. This helps to prevent oxidative stress that would otherwise harm the aerobic life, forms due to imbalance created between the rates of production and removal of reactive oxygen species (ROS) in the biological cells. Recently Carbon Dots(CD), owing to the functional groups (-COOH and non-phenolic –OH) present at the surface of nanoparticle as well as their biocompatibility, enable to exhibit the scavenging activity towards various ROS which helps to explore their antioxidant properties. Although, few reports have been demonstrated on scavenging activity of carbon dots (CDs) against DPPH radical, owing to their abundance of surface functional group and reasonable cytotoxicity, the investigations of the antioxidant property of CDs are still in their initial stages and limited to the scavenging of DPPH radicals only. In this light, N, S co-doped carbon dots were synthesized using tartaric acid and thio-urea, to exhibit the scavenging of various free radical/ROS, such as, DPPH free radical, hydroxyl free radical, superoxide anion, KMnO<sub>4</sub> and peroxide, by UV-Vis spectroscopy. Electron paramagnetic resonance spectroscopy and pH dependent UV spectroscopy studies revealed hydrogen atom transfer (HAT) mechanism of scavenging through DPPH assay. We believed that the findings would be helpful to explore the antioxidant property of CDs.

Exploring the antioxidant property of N, S co-doped carbon dots: A mechanistic overview

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ACS Fall 2022

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