Plant based biomaterials are good alternatives against resistant microorganisms and antimicrobial resistance. Plants have since history mechanisms, which help them survive against dangerous pathogens. Aloe Vera (AV) is used in many civilizations as medicinal plant with many applications, including inhibitiory action on many pathogens. Trans-cinnamic acid (TCA) is a natural ingredient in many plants and is known and used for its antimicrobial properties. Iodine (I2) is an excellent, non-toxic microbicide and available as polyvinylpyrrolidone (PVP) complex, called povidone iodine (PVP-I2), which acts as a iodophor. We prepared a sustainable formulation based on previous investigations according to the system AV-PVP-TCA-I2. The analytical results on SEM, EDS, Raman, XRD, UV-vis and FTIR confirm the morphology and composition of the biocomplex. The biohybrid has excellent antifungal and very good antibacterial properties against 10 reference bacterial strains in comparison to the common antibiotics gentamycin and nystatin. We investigated the title compound on sutures, bandages, as well as surgical face mask tissues to investigate infection control potential of AV-PVP-TCA-I2. Our title compound has potential in the prevention of surgical-site and wound infections, as well as surface killing abilities. Further in-vivo investigations are needed to ensure the antimicrobial action of AV-PVP-TCA-I2.

Antimicrobial aloe-vera-trans-cinnamic acid iodine complex for infection control on surfaces

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