Many organic molecules can crystallize as hydrates and/or other solvate forms.  While not all solvates have properties suitable for commercial development, they can serve as important precursor phases which, upon process-induced desolvation, yield crystal forms that may not be accessible through conventional growth methods.  Yet predicting the products and mechanistic pathway(s) by which desolvation reactions occur remains a real challenge.  Niclosamide, a WHO Essential Medicine used in the treatment of parasite infections, crystallizes in multiple solvate forms with different 3-D topologies.  Using a combination of time-resolved X-ray diffraction and thermogravimetric methods, here we compare and contrast the mechanisms, kinetics, and structural changes associated with process-induced desolvation from four different niclosamide solvates.

Process-induced desolvation of solvates

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