Aniracetam belongs to a family of compounds known as racetams. These compounds have been shown to be capable of binding to neuroreceptors and have been applied as treatments for central nervous system disorders. However, the exact mode of action of these compounds has not been elucidated. Development of racetam/ racetam derivative radiotracers would enable <i>in vivo</i> study of these compounds. The safe synthesis of radiotracers necessitates reagents be manipulated inside a hot cell to mitigate human exposure to radiation. This has been accomplished through manual mechanical manipulators, microfluidics, and other automation systems. A potential radiotracer for brain imaging, based on aniracetam, had previously been reported using a microfluidic system. We wish to report the synthesis of the title compound on the automated synthetic platform Elixys Flex/Chem. This alternative automated system is cassette based and uses a robotic arm. The product was obtained with a radiochemical yield of 21% (non-decay corrected), as determined by radio-TLC. Furthermore, the synthesis of the radiotracer precursor was improved. Application of a guanidine base during a deprotection step afforded a phenol intermediate with a yield of 90%. This was a 50% increase in yield, compared to the established deprotection method.

Synthesis of N-[4(2’-[18F]fluoroethyloxybenzoyl)]pyrrolidine-2one by ELIXSY flex/chem automation system

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.