The stability of nanojars of the formula [{Cu(OH)(Rpz)}nCO3]2− (pz = pyrazole derivative; R = H, 4-(CH3OCH2CH2O) or 4-(CH3(OCH2CH2)3O); n = 27, 29, 31) in the presence of biological molecules found in human body fluids was studied using electrospray ionization mass spectrometry (with small biomolecules) and UV-vis spectroscopy (with proteins and serum). Lipids (triglycerides and cholesterol), glucose, urea, uric acid, creatine, creatinine, amino acids (glycine, alanine, glutamic acid, tyrosine), bilirubin, adenine, ascorbic acid, albumin, γ-globulin and fibrinogen display varying degrees of reactivity towards nanojars, ranging from no interaction to substitution of nanojars by pyrazolate ligand replacement to complete nanojar breakdown. In addition, the stability of nanojars in human serum solutions was also investigated.

Evaluation of the interaction of nanojars with biomolecules found in human body fluids

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.