The peroxyoxalate system – base catalyzed reaction of reactive oxalate esters with hydrogen peroxide in the presence of a fluorescent compound – constitutes one of the most efficient chemiluminescence (CL) transformations known, with emission quantum yields of up to around 50 %. In aqueous medium, the emission quantum yields of this reaction are several orders of magnitude lower than those obtained in anhydrous organic solvents A significant barrier to the use of peroxyoxalate chemiluminescence in aqueous systems has been the propensity to hydrolysis of reactive oxalate derivatives. We report here kinetic studies on the emission characteristics of a peroxyoxalate system based on oxalic ester and activator loaded microspheres of cellulose derivatives. The emission quantum yields determined for these systems are two orders of magnitude higher than those obtained in aqueous medium under directly comparable conditions. These results indicate that the encapsulation of reagents of the peroxyoxalate system can be a promising approach for its advantageous utilization in analytical and bioanalytical assays in aqueous media.

Chemiluminescence emission efficiency of peroxyoxalate system improved by cellulose microspheres

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ACS Fall 2022

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