Gold nanostars (GNSs) have enhanced surface-to-volume ratios (aspect ratios) and unique crystallinities within the core and spikes. This results in improved light harvesting and catalytic efficiencies. GNSs were prepared, using multiply twinned triblock-copolymer gold nanoparticle (GNP) seeds, added to a growth solution of partially reduced gold salts. High yield and reproducibility were obtained. Nanoparticle tracking analysis was used to measure GNS sizes, concentrations, and relative scattering intensities. Tip length-to-core aspect ratio of the GNSs was varied by adjusting the gold salt to seed ratio. Surface PEGylation enhanced the biocompatibility and catalytic performance, while eliminating the surfactant from the GNSs growth solution. Catalysis model employed the borohydride reduction of the organic pollutant 4-nitrophenol to 4-aminophenol. The obtained rate constants were comparable to citrated gold nanoparticles, with turnover frequency independent of the aspect ratio. Monte Carlo simulation calculations showed dose enhancement with high energy photons and high linear energy neutrons. Future studies include a) cellular uptake, b) cytotoxicity toward U87 cell line, isolated from malignant gliomas with epithelial morphology, and c) targeted radiation induced DNA damage.

Gold nanostars: Functionalization, catalysis, and biocompatibility

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ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.