In this talk I will discuss our recent efforts to utilize phenyl and vinyl carbocations in stereoselective C–H functionalization reactions. We will describe how these high-energy dicoordinated carbocations can be generated under mild conditions and utilized in the selective C–C bond forming reactions of simple hydrocarbons. Moreover, we will discuss our efforts to understand the mechanism of these reactions through computational chemistry, kinetics, electron microscopy, and isotopic labeling studies. In the second half of the talk we will discuss our efforts to bring electron microscopy to organic chemistry through the use of MicroED and other CryoEM modalities.

C–H functionalization reactions of vinyl carbocations and MicroED in natural product discovery

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.