We report a cationic porphyrin 5,10,15,20-tetrakis-(4-N-methylpyridyl)-porphyrin (TMPyP) that can respond to specific bacteria, followed by adaptable photodynamic/photothermal therapy process. TMPyP could be reduced to phlorin by facultative anaerobes with strong reducing ability such as <i>E. coli</i> and <i>S. typhimurium</i> in hypoxic environments, possessing strong NIR absorption and remarkable photothermal conversion capacity, thus demonstrating excellent antimicrobial activity (&gt; 99%) by photothermal therapy. While in an aerobic environment with aerobic bacteria, TMPyP functioned as a typical photosensitizer which killed bacteria effectively (&gt; 99.9%) by photodynamic therapy. By forming host-guest complex with cucurbit[7]uril, the biocompatibility of TMPyP significantly improved. This kind of bacteria-responsive porphyrin shows specificity and adaptivity in antimicrobial treatment and holds potentials in non-invasive treatment of bacterial infections.

Bacteria-responsive porphyrin for adaptable photodynamic/photothermal therapy

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ACS Fall 2022

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