Rhodium-catalyzed decarbonylation reactions have been shown to occur readily with a variety of substituted 2-pyridyl-substituted benzophenones. However, the 2,6-<i>diortho</i>-fluoro pyridyl ketone fails to undergo decarbonylation. It was found that treatment of these compounds with boronic acids leads to an aryl ring exchange and subsequent decarbonylation. This decarbonylation-exchange reaction was further optimized by evaluating three promising sets of experimental conditions with a variety of boronic acids.

Carbon-carbon bond activation: Optimization of decarbonylation-exchange reactions of 2-pyridyl benzophenones with boronic acids

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