Methods for the automated high-fidelity chemical production of proteins are needed. Proteins manufactured with mechanical machines, as opposed to bio-based systems, can bulletproof production circumventing endotoxin contamination and cell-line variability. Further, chemical synthesis enables the ability to rewire the covalent framework with non-natural amino acids, drugs, and carbohydrates. I will discuss the fully automated single-shot chemical synthesis of protein chains up to 220 amino acids in hours. After purification and folding, the synthetic proteins functioned analogously to ribosomally produced material. In addition, rapid protein synthesis enables accelerated drug discovery when combined with our single-shot affinity-selection mass spectrometry platform. I will discuss our results toward the discovery of high-affinity peptidomimetics that target oncoproteins or SARS-CoV-2.

Rapid response technologies for protein manufacturing, delivery and drug discovery

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.