With many diseases early detection is critical for a favorable patient outcome. Chronic Kidney Disease (CKD) is an example. In many cases, CKD develops without any symptoms and progresses into renal failure before it is detected. Current clinical diagnosis involves the detection of a patient’s creatinine concentration in blood samples and the calculation of the estimated Glomerular Filtration Rate (eGFR). This research project explored the use of surface enhanced Raman scattering (SERS) with 20 nm silver nanoparticles to detect and quantify the creatine levels in synthetic blood samples as a potential rapid point of care diagnostic solution to this challenge. The detection of Cystatin-C, another CKD biomarker, levels was also demonstrated increasing the accuracy of eGFR calculation. A SERS approach has the advantages of simplicity, low cost, speed, high sensitivities, and the potential to be developed into a handheld point of care diagnostic device.

A new diagnostic method for chronic kidney disease using surface enhanced Raman spectroscopy

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.