The literature evidence shows that the excessive use of antibiotics has created many threats to human health. The comparative treatment study of patients suffering acute intestinal diseases (amebiasis and dysentery) with traditionally antibiotic dosage (metronidazole, tetracycline, and ciprofloxacin) therapy and new formula congaing antibiotics with low methoxylated and high methoxylated apple pectins includes four clinical trials has been performed in 1989-1990 and 2013-2018 years at the Infection Disease Hospital, Dushanbe, Tajikistan. The statistical analysis of efficiency of these comparative studies as a percentage of patient’s recovery has demonstrated that using the pectin formula significantly reduced the severity of acute intestinal infection diseases and allowed patients to recover in a shorter time than conventional treatment. Analysis of the dynamics of mean antibiotic concentration value distribution per day of the study showed that the drug concentration level was maintenance steady in the blood plasma of 6 patients who received new pectin formula on the treatment days 3 and 6. In the case of traditionally antibiotic and sugar water solution formula administration, drug concentration levels decreased up to 5 to 15 mg/L. There was also a clinical improvement in patients who received both pectin formulae. Thus, four clinical trials demonstrated the application of apple pectin containing polyphenols and antibiotics in therapy of infected patients provides a synergetic effect to antibiotic treatment. The administration of pectin against the antibiotic background has allowed maintaining its constant concentration in the blood, leading to an acceleration of the clinical recovery of patients.

A new approach on the treatment of acute infection diseases by antibiotic-pectin formulae

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