While polar perfluoroalkyl derivatives (typically RF-COOH/SO3H surfactants) are being phased out due to environmental concerns, the less polar RF-X (X = Cl, Br, I) halides are much less detrimental and remain very important building blocks in organic, organometallic, pharma, agricultural and polymer chemistry. However, their synthesis follow dissimilar pathways and are commercially available with a largely skewed offering of Cl &gt;&gt; Br &gt;&gt; I, whereas iodine derivatives are most desired in synthesis. Unfortunately, due to the strong deactivating effect of fluorine, nucleophilic substitution pathways and blocked and typical e.g. NaI/acetone of RF-Cl to RF-I interconversions are not applicable. We are currently developing methods for such metal catalyzed processes by radical or organometallic pathways. This presentation will describe a systematic study of the effect of various parameters (nature of the metal, ligand, solvent, temperature, halide substrate and source) towards optimizing the efficiency and understanding the mechanism of these transformations.

Towards metal mediated perfluoroalkyl halide interchange.

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Towards metal mediated perfluoroalkyl halide interchange.</i>