Three-membered rings are important synthetic targets. They are versatile intermediates due to their proclivity towards ring opening and are also useful pharmacophores in medicines. However, their synthesis typically necessitates high energy reagents to offset the energetic penalty of ring strain. This seminar will describe a new strategy to prepare three-membered ring systems from alkenes and common classes of nucleophiles. The key to the strategy discussed is the electrochemical generation of a reactive dielectrophilic adduct between the alkene substrate and thianthrene.

Strained ring synthesis via electrochemical dication pool

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.