With excellent magnetic properties and good biocompatibility, Fe3O4 nanoparticles (NPs) have been extensively explored for use in various biomedical applications such as cancer treatment, magnetic imaging, and biosensing. In this work, we focused on the synthesis and study of the nanostructure, crystallinity, and magnetic properties of Fe3O4 NPs having two different geometries, nanospheres (NSs) and nanocubes (NCs). For spherical NPs, boosting the crystallinity and tuning the size of the particles were the two main targets. Specifically, we prepared Fe3O4 NPs with diameters ranging from 50 to 250 nm and crystallite sizes from 10 to 34 nm. Importantly, all of the synthesized spherical Fe3O4 NPs exhibited either ferrimagnetic or superparamagnetic behavior. In addition, we synthesized Fe3O4 nanocubes of comparable dimensions to compare their magnetic properties with the highly crystalline nanospheres. Functionalization of all of the nanoparticles with biotin (vitamin B7) will enable systematic studies of their biosensing capacity as magnetic labeling agents in force-induced remnant magnetization spectroscopy (FIRMS).

Syntheses, structures, and magnetic properties of fe3O4 nanoparticles for biosensing using force-induced remnant magnetization spectroscopy

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